Immune System Dysregulation

Your immune system is critical to your well being. Yet these days so many people suffer from allergies, auto immune diseases or cancer.

There are diverse causes and treatments for immune dysregulation, though through a holistic approach you give your body the best chance of putting out the fire of inflammation, resetting the system, and restoring vitality. We create a personalised plan for you, and explain the why behind the why, rather than just trying to treat your symptoms.

We treat all immune issues including allergies, CIRS, and autoimmune diseases. CIRS is increasingly common, and Dr Anne Chappel and Dr Chris Chappel are trained in how to test for and treat this complex health problem.

Chronic Inflammatory Response Syndrome (CIRS)

CIRS (sometimes known as Biotoxin Illness) is a massive immune response to a wide variety of things including mould toxins (mycotoxins), or other toxins which may be related to infections. People with CIRS cannot properly present mould to their immune system. Mould itself can go only as far as the mucous membranes, but the mould toxin can get into the blood stream and then into the nervous system.

Like all medical syndromes, CIRS is characterized by a cluster of symptoms. CIRS symptoms may include visual disturbances, fatigue, cognitive decline, body aches, mood changes, unusual pains or skin sensations and sinus or breathing difficulties.

CIRS patients can become more and more ill as time passes if they are being constantly exposed to the triggering agent. And thus the develop chronic multiple fluctuating symptoms.  It is no use treating individual symptoms and trying to suppress them. The true underlying pathways need to be assessed and treated. This includes removal of the biotoxin, increasing detoxification pathway function and supporting and enhancing mitochondrial function within the cells.

This is our approach to patients with CIRS and to all chronically ill people. It is vitally important to seek the underlying causal mechanisms and to treat those. CIRS is more common in genetically predisposed persons (however, this is 25% of the population!) and we can test for this in blood panels. The genes that make you susceptible to CIRS are involved in multiple pathways, including important detoxification pathways.

Unfortunately patients with CIRS often get bounced around the health system and spend years without a clear understanding of the cause of their symptoms as they can appear to be quite separate to doctors not familiar with CIRS. It’s very important that no underlying diseases are missed and therefore patients need to have a thorough work up, by a suitability trained doctor. If you do have CIRS and the real causes are found, with the right treatments most patients make a full recovery.

The Department of Health in a committee review on the 8th of October 2018 observed commonalities between many symptoms of CIRS and those associated with CFS and Lyme disease. 56

Reported symptoms associated with CIRS include combinations of things like:


- Fatigue
- Weakness
- Aches
- Muscle cramps
- Sharp pain
- Headache
- Light sensitivity
- Joint pain
- Morning stiffness
- Memory issues
- Difficulty with focus/concentration
- Word finding difficulties
- Decreased assimilation of new knowledge
- Confusion
- Disorientation
- Skin sensitivity
- Mood swings
- Sweats (especially night sweats)
- Temperature regulation or dysregulation problems
- Vertigo/Dizziness

- Red eyes
- Blurred vision
- Tearing
- Sinus problems
- Cough
- Shortness of breath
- Excessive thirst despite frequent water intake
- Static shocks
- Numbness
- Tingling
- Metallic taste
- Abdominal pain
- Diarrhoea
- Tremors 50
- Unusual pain 51
- Migraine/facial pain 52
- Appetite swings 53
- Increased urination 54/ nocturia 55
- Sensitivity to electromagnetic fields like mobile phones


Common misdiagnoses given to CIRS patients include:


- Chronic Fatigue Syndrome (CFS)
- Fibromyalgia
- Somatization (such as Hypochondria)
- Attention Deficit Hyperactivity Disorder (ADD/ADHD

- Depression and Anxiety
- Allergies
- Irritable Bowel Syndrome (IBS)
- Post-traumatic Stress Disorder (PTSD)


Book an appointment with Evergreen Doctors today to clarify if you have CIRS and get you back on the road to wellness.